Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes
Identifieur interne : 002A67 ( Main/Exploration ); précédent : 002A66; suivant : 002A68Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes
Auteurs : Mary Anne Campbell [États-Unis] ; S. Bandiera [États-Unis] ; L. Robertson [États-Unis] ; A. Parkinson [États-Unis] ; S. Safe [États-Unis]Source :
- Toxicology [ 0300-483X ] ; 1982.
Abstract
Pretreatment of immature male Wistar rats with 1,2,3,4,5,6,7-hepta-, 1,2,3,4,5,6,8-hepta- and 1,2,3,4,5,6-hexachloronaphthalene resulted in the induction of several hepatic microsomal drug-metabolizing enzymes. The enzymic activities, reduced cytochrome P-450: CO and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase, 3-methylcholanthrene. The 1,2,3,4,5,6,7-heptachloronaphthalene congener, which is fully substituted in the lateral 2,3,6 and 7 positions, was more potent than the 1,2,3,4,5,6,8-hepta- and the 1,2,3,4,5,6-hexachloronaphthalene congeners which contain only 3 lateral chloro substituents. 1,2,3,4-Tetra- and several lower chlorinated naphthalenes were inactive as inducers of microsomal aryl hydrocarbon hydroxylase. The effects of structure on the induction activities of the polychlorinated naphthalenes were similar to those observed for other halogenated aryl hydrocarbons.
Url:
DOI: 10.1016/0300-483X(83)90081-1
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title><author><name sortKey="Campbell, Mary Anne" sort="Campbell, Mary Anne" uniqKey="Campbell M" first="Mary Anne" last="Campbell">Mary Anne Campbell</name></author><author><name sortKey="Bandiera, S" sort="Bandiera, S" uniqKey="Bandiera S" first="S." last="Bandiera">S. Bandiera</name></author><author><name sortKey="Robertson, L" sort="Robertson, L" uniqKey="Robertson L" first="L." last="Robertson">L. Robertson</name></author><author><name sortKey="Parkinson, A" sort="Parkinson, A" uniqKey="Parkinson A" first="A." last="Parkinson">A. Parkinson</name></author><author><name sortKey="Safe, S" sort="Safe, S" uniqKey="Safe S" first="S." last="Safe">S. Safe</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CC49E438021EB5C75312154D7F889A6D2B4DAE77</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1016/0300-483X(83)90081-1</idno><idno type="url">https://api.istex.fr/document/CC49E438021EB5C75312154D7F889A6D2B4DAE77/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002231</idno><idno type="wicri:Area/Main/Curation">001F17</idno><idno type="wicri:Area/Main/Exploration">002A67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes</title><author><name sortKey="Campbell, Mary Anne" sort="Campbell, Mary Anne" uniqKey="Campbell M" first="Mary Anne" last="Campbell">Mary Anne Campbell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="subField">N1G 2W1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Bandiera, S" sort="Bandiera, S" uniqKey="Bandiera S" first="S." last="Bandiera">S. Bandiera</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="subField">N1G 2W1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Robertson, L" sort="Robertson, L" uniqKey="Robertson L" first="L." last="Robertson">L. Robertson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station</wicri:cityArea></affiliation></author><author><name sortKey="Parkinson, A" sort="Parkinson, A" uniqKey="Parkinson A" first="A." last="Parkinson">A. Parkinson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="subField">N1G 2W1 Canada</wicri:noCountry></affiliation></author><author><name sortKey="Safe, S" sort="Safe, S" uniqKey="Safe S" first="S." last="Safe">S. Safe</name><affiliation><wicri:noCountry code="no comma">To whom correspondence should be sent.</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A & M University, College Station</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology</title><title level="j" type="abbrev">TOX</title><idno type="ISSN">0300-483X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982">1982</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">3–4</biblScope><biblScope unit="page" from="193">193</biblScope><biblScope unit="page" to="205">205</biblScope></imprint><idno type="ISSN">0300-483X</idno></series><idno type="istex">CC49E438021EB5C75312154D7F889A6D2B4DAE77</idno><idno type="DOI">10.1016/0300-483X(83)90081-1</idno><idno type="PII">0300-483X(83)90081-1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-483X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pretreatment of immature male Wistar rats with 1,2,3,4,5,6,7-hepta-, 1,2,3,4,5,6,8-hepta- and 1,2,3,4,5,6-hexachloronaphthalene resulted in the induction of several hepatic microsomal drug-metabolizing enzymes. The enzymic activities, reduced cytochrome P-450: CO and ethylisocyanide binding difference spectra and electrophoretic mobilities of the induced microsomal proteins were comparable to those observed after administration of the classical inducer of microsomal aryl hydrocarbon hydroxylase, 3-methylcholanthrene. The 1,2,3,4,5,6,7-heptachloronaphthalene congener, which is fully substituted in the lateral 2,3,6 and 7 positions, was more potent than the 1,2,3,4,5,6,8-hepta- and the 1,2,3,4,5,6-hexachloronaphthalene congeners which contain only 3 lateral chloro substituents. 1,2,3,4-Tetra- and several lower chlorinated naphthalenes were inactive as inducers of microsomal aryl hydrocarbon hydroxylase. The effects of structure on the induction activities of the polychlorinated naphthalenes were similar to those observed for other halogenated aryl hydrocarbons.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Campbell, Mary Anne" sort="Campbell, Mary Anne" uniqKey="Campbell M" first="Mary Anne" last="Campbell">Mary Anne Campbell</name></region><name sortKey="Bandiera, S" sort="Bandiera, S" uniqKey="Bandiera S" first="S." last="Bandiera">S. Bandiera</name><name sortKey="Parkinson, A" sort="Parkinson, A" uniqKey="Parkinson A" first="A." last="Parkinson">A. Parkinson</name><name sortKey="Robertson, L" sort="Robertson, L" uniqKey="Robertson L" first="L." last="Robertson">L. Robertson</name><name sortKey="Safe, S" sort="Safe, S" uniqKey="Safe S" first="S." last="Safe">S. Safe</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:CC49E438021EB5C75312154D7F889A6D2B4DAE77
|texte= Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes
}}
| This area was generated with Dilib version V0.6.23. |  |